This Socio-Economic Study brings together a comprehensive assessment of the socio-economic impacts of the tsetse fly eradication campaign implemented in the Niayes area of Senegal. It describes the intervention strategy, methodological framework, qualitative and quantitative data collection, and the use of propensity score matching (PSM) to evaluate outcomes on livestock productivity, household income, and disease prevalence. The report serves as a valuable resource for policymakers, researchers, and development practitioners seeking to understand the broader implications of vector control interventions on rural livelihoods and livestock systems. The Socio-Economic Study is available in English and French.