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Unlocking the Potential of the Oncological Toolkit

Despite its importance in supporting new tools and techniques to tackle cancer, research is often limited in resource-challenged contexts where health professionals cite a lack of training in methodology as a major barrier. (Photo: IAEA)

The IAEA and the University of Texas MD Anderson Cancer Center, an IAEA Collaborating Centre in Human Health, are strengthening the research capabilities of cancer centres across the globe through a year-long teaching programme. The initiative brings together experts, clinicians and researchers from around the world, including from Rays of Hope Anchor Centres, for monthly webinars and group discussions to enhance scientific inquiry in oncology. 

 “Research plays a critical role in encouraging novel advances, new techniques and innovative approaches for tackling cancer,” said May Abdel-Wahab, Director of the IAEA Division of Human Health. “Yet despite its importance, most of this research is being carried out in high-income countries, which commonly have different cancer contexts, profiles and priorities from their low and middle-income counterparts, where nearly three-quarters of all cancer deaths are projected to occur by 2030.”  

 A 2022 review of radiation therapy trials published between 2014 and 2017 found that over 75% were performed in high-income countries while only 13% were carried out solely in low — and middle-income countries. A recent analysis of funding sources and radiotherapy research outputs further highlighted this imbalance across incomes and cancer disease sites.  

 “Cancer specialists in resource-challenged settings often cited the lack of training in methodology as a major barrier to conducting research,” Abdel-Wahab noted, as one of the lead authors. The 2024 Lancet Oncology Commission on Radiotherapy and Theranostics has also urged greater support for clinical trials to guide best uses and facilitate implementation can increase access to radiotherapy. 

Addressing Research Challenges

To help close this gap, the IAEA and MD Anderson Cancer Center in the United States have created a joint course on clinical research and research methodologies. Coordinated by experts from the IAEA’s human health programme and from MD Anderson, the monthly lectures cover systematic literature reviews, epidemiology, research ethics, study design, data collection and database management. Sessions also focus on specific research designs including retrospective and prospective cohort studies, clinical trials, quality improvement studies and implementation research.  

 “MD Anderson is proud to partner with the IAEA on the Research Training Course for Anchor Centres. Under the leadership of Dr Elizabeth Chiao and Dr Lilie Lin, our faculty are honoured to share their expertise and collaborate with colleagues to strengthen and expand research efforts,” said Kathleen Schmeler, associate vice president of Global Oncology and professor of Gynecologic Oncology and Reproductive Medicine at MD Anderson Cancer Center. “As an IAEA Collaborating Centre, we remain committed to advancing progress and reducing the global burden of cancer.” 

Elizabeth Chiao – professor at MD Anderson Cancer Center’s Department of Epidemiology and its Department of General Oncology – leading one of the lectures on research methodology. (Photo: IAEA)

Hundreds of professionals in radiation oncology, radiology, nuclear medicine, medical physics, nutrition and other disciplines have participated in the lectures, fostering a culture of collaboration and research. At each session, participants from Rays of Hope Anchor Centres present on the month’s topic — sharing how their institutions apply research principles into practice. This regular exchange of experiences strengthens peer learning among cancer facilities and promotes the adoption of good practices.  

“Participating in the year-long lecture series with MD Anderson and the IAEA has been an exceptional opportunity for our Anchor Centre. The lectures have provided not only cutting-edge methodological tools but also practical perspectives to improve research protocols, data quality and multidisciplinary collaboration,” said Valentin J. Ugarte Ferrero, Coordinator for Academic Activities at the National Atomic Energy Commission, Institute of Nuclear Technology for Health in Argentina. “These learnings will be integrated into our training programmes and future research projects, strengthening our role as a regional hub for innovation and excellence in patient-centred cancer care.” 

“The lecture series’ approach to clinical research and methodology combines innovation with scientific rigor, strengthening our ability to implement evidence-based protocols and prioritize patient-centred research design,” added Mike Sathekge, Head of Nuclear Medicine Department at Steve Biko Academic Hospital, the Anchor Centre in South Africa. 

Recordings of the monthly sessions will be made available on demand via the Human Health Campus at the conclusion of the lecture series. 

Scientists presenting their research at the IAEA’s International Conference on Advances in Radiation Oncology, June 2025. (Photo: IAEA)

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