The IAEA and the Argonne National Laboratory (USA) jointly organized a Training course on Strategic Planning/Management for young leaders of the Latin America and Caribbean region, from November 2020 to February 2021, under Technical Cooperation project RLA0069 "Promoting Strategic Management and Innovation at National Nuclear Institutions through Cooperation and Partnership Building -Phase II (ARCAL CLXXII)". This course collects the lectures presented, which are relevant to all other regions as well. The course covers topics such as: Stakeholders; Threat Analysis & Strategic Considerations; Action Planning & Reviewing; Facility Operations and Management; Organizational Structure & Personnel development; Finance; Outreach and Marketing; Change Management. Different types of facilities are considered, including Research Reactors; Gamma Irradiation; Production of Radiopharmaceuticals or radioisotopes; E-beam accelerators; Calibration services; Analysis services (isotope hydrology, NDTs, etc).