This course is part of?The Applied Sciences of Oncology (ASO) distance-learning course.Aim:?To provide an understanding of the basic molecular biology and pathogenesis of malignancies.ObjectivesUpon completion, participants should be able to:Describe genetic basis of malignancy.Discuss genetic models for pathogenesis of?colorectal and breast cancerDiscuss the role of pathology and molecular pathology in cancer diagnosis and treatmentDiscuss?prevalence and epidemiology of oncogenic infectious agents and their associated malignanciesDiscuss?rare genetic susceptibility to malignancy