This Safety Report compares the requirements of IAEA Safety Series No. 50-C/SG-Q, Quality Assurance for Safety in Nuclear Power Plants and other Nuclear Installations (1996), with the ISO 9001:2000 standard issued by the International Organization for Standardization. It identifies the main differences between the ISO quality standards and the additional requirements and guidance contained within the IAEA standard. It also provides information and guidance that may be considered when ISO 9001:2000 and ISO 9004:2000 are utilized by the nuclear industry.